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The problem, however, is that there are lots of other tiny targets on the wall. Once all those other targets are factored in, is it still unlikely that the archer could have hit any of them by chance? In addition, we need to factor in what I call the replicational resources associated with T, that is, all the opportunities to bring about an event of T's descriptive complexity and improbability by multiple agents witnessing multiple events. According to Dembski, the number of such "replicational resources" can be bounded by "the maximal number of bit operations that the known, observable universe could have performed throughout its entire multi-billion year history", which according to Lloyd is 10120.

Natural selection can lead to complex biochemical systems being built up from simpler systems, or to existing functional systems being recombined as a new system with a different function. For example, one of the clotting factors that Behe listed as a part of the clotting cascade was later found to be absent in whales, demonstrating that it is not essential for a clotting system. Many purportedly irreducible structures can be found in other organisms as much simpler systems that utilize fewer parts.

Complex specified information detects design because it detects what characterizes intelligent agency; it detects the actualization of one among many competing possibilities. A study by Wesley Elsberry and Jeffrey Shallit states that "Dembski's work is riddled with inconsistencies, equivocation, flawed use of mathematics, poor scholarship, and misrepresentation of others' results". Another objection concerns Dembski's calculation of probabilities. According to Martin Nowak, a Harvard professor of mathematics and evolutionary biology "We cannot calculate the probability that an eye came about.

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