By M.L. Silverstein

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Hastings, N. , 2000, Statistical Distributions, 3rd edn, J. ] Beta error: Synonym for type II error. Beta-geometric distribution: A probability distribution arising from assuming that the parameter of a geometric distribution has a beta distribution. The distribution has been used to model the number of menstrual cycles required to achieve pregnancy. ] Between-groups sum of squares: See analysis of variance. 24 Bias: Deviation of results or inferences from the truth, or processes leading to such deviation.

R Phase II study: Once a drug has been established as safe in a phase I study, the next stage is to conduct a clinical trial in patients to determine the optimum dose and to assess the efficacy of the compound. r Phase III study: Large multicentre comparative clinical trials to demonstrate the safety and efficacy of the new treatment with respect to the standard treatments available. These are the studies that are needed to support product licence applications. r Phase IV study: Studies conducted after a drug is marketed to provide additional details about its safety, efficacy and usage profile.

From this relationship, the total number of individuals in the population can be estimated. Used originally to estimate the size of animal populations, the method is now also used to assess the size of many populations of great interest in medicine, for example the number of drug users in a particular area or the completeness of cancer registry data. ] Carrier: A person that harbours a specific infectious agent in the absence of discernible clinical disease and serves as a potential source of infection.

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